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KMID : 0613820170270040417
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Journal of Life Science
2017 Volume.27 No. 4 p.417 ~ p.422
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Anti-inflammatory Activities Verification of Vaccinum oldhami Fruit Ethanol Extracts on RAW 264.7
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Lee Jin-Young
Joo Da-Hye
Yoo Dan-Hee
Chae Jung-Woo
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Abstract
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The purpose of this study was to investigate the role of the Vaccinum oldhami fruit extract as a cosmetic additive. As a result of having macrophage (RAW 264.7) measured a cell toxicity effects of 70% ethanol extract from Vaccinum oldhami fruit, it shown 118% with toxicity at 500 μg/ml concentration. In nitric oxide synthesis inhibition effect, 70% ethanol extracts from Vaccinum oldhami fruit shown 47.3% at 1,000 μg/ml concentration. The iNOS, COX-2 protein expression inhibitory effect by western blot of 70% ethanol extract from Vaccinum oldhami fruit was decreased by 36.13%, 29.61% at 500 μg/ml concentration. And iNOS, COX-2 mRNA expression inhibitory effect by reverse-transcription-PCR of 70% ethanol extract from Vaccinum oldhami fruit was decreased by 62.25%, 90.07% at 500 μg/ml concentration. All these finding that extract from Vaccinum oldhami fruit could prove that their have effects anti-inflammatory efficacy. And extract from Vaccinum oldhami fruit has potential as a cosmetic ingredients.
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KEYWORD
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Anti-inflammatory, Vaccinum oldhami fruit, iNOS, COX-2, western, reverse-transcription- PCR
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